Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNTHETIC FUSION PROTEINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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graph TD
SYNTHETIC_FUSION_PROTEINS["SYNTHETIC FUSION PROTEINS"]
SYNTHETIC_FUSION_PROTEINS -->|"studied_in"| neurodegeneration["neurodegeneration"]
SYNTHETIC_FUSION_PROTEINS -->|"debate_co_mention"| TFAM["TFAM"]
SYNTHETIC_FUSION_PROTEINS -->|"debate_co_mention"| TRAK1_KIF5A["TRAK1_KIF5A"]
GAP43["GAP43"] -->|"debate_co_mention"| SYNTHETIC_FUSION_PROTEINS
GJA1["GJA1"] -->|"debate_co_mention"| SYNTHETIC_FUSION_PROTEINS
PRKAA1["PRKAA1"] -->|"debate_co_mention"| SYNTHETIC_FUSION_PROTEINS
RAB27A["RAB27A"] -->|"debate_co_mention"| SYNTHETIC_FUSION_PROTEINS
PARKIN["PARKIN"] -->|"debate_co_mention"| SYNTHETIC_FUSION_PROTEINS
PINK1["PINK1"] -->|"debate_co_mention"| SYNTHETIC_FUSION_PROTEINS
RHOT1["RHOT1"] -->|"debate_co_mention"| SYNTHETIC_FUSION_PROTEINS
RAB27A_LAMP2B["RAB27A/LAMP2B"] -->|"debate_co_mention"| SYNTHETIC_FUSION_PROTEINS| Target | Relation | Type | Str |
|---|---|---|---|
| TFAM | debate_co_mention | gene | 0.45 |
| TRAK1_KIF5A | debate_co_mention | gene | 0.45 |
| neurodegeneration | implicated_in | disease | 0.40 |
| GJA1 | co_discussed | gene | 0.40 |
| neurodegeneration | associated_with | disease | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-495454ef | targets_gene | hypothesis | 0.90 |
| h-495454ef | targets | hypothesis | 0.50 |
| PARKIN | debate_co_mention | gene | 0.45 |
| PINK1 | debate_co_mention | gene | 0.45 |
| RHOT1 | debate_co_mention | gene | 0.45 |
| RAB27A/LAMP2B | debate_co_mention | gene | 0.45 |
| GAP43 | debate_co_mention | gene | 0.45 |
| GJA1 | debate_co_mention | gene | 0.45 |
| PRKAA1 | debate_co_mention | gene | 0.45 |
| RAB27A | debate_co_mention | gene | 0.45 |
| LAMP2B | co_discussed | gene | 0.40 |
| ChR2 | co_discussed | gene | 0.40 |
| BNIP3 | co_discussed | gene | 0.40 |
| BNIP3L | co_discussed | gene | 0.40 |
| RHOT1 | co_discussed | gene | 0.40 |
| PANX1 | co_discussed | gene | 0.40 |
| RAB27A | co_discussed | gene | 0.40 |
| GJA1 | co_associated_with | gene | 0.40 |
| ChR2 | co_associated_with | gene | 0.40 |
| RHOT1 | co_associated_with | gene | 0.40 |
| RAB27A/LAMP2B | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Synthetic Biology Approach: Designer Mitochondrial Export Sy | 0.627 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.692
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Integrating biocatalysis with continuous flow: current status, challenges, and f [PMID:40639553] | Bai J, Huang C, Liu Y, Zheng X, Liu J et | J Adv Res | 2026 | 0 |
| Engineering chimeric signaling proteins for microbial whole-cell biosensors: fro [PMID:40903364] | Özer Bergman G, Mecacci S, Martins Dos S | Trends Biotechnol | 2026 | 0 |
| MTAP Deletion in Oncogenesis: A Synthetic Lethality Scenario. [PMID:41512197] | Rodon J, Johnson ML, George B, Shah PA, | Cancer Res | 2026 | 0 |
| Design and synthesis of BAP-1 inhibitors. [PMID:41761813] | Zhang Z, Yang X | Pak J Pharm Sci | 2026 | 0 |
| Optimized bacterial expression of a synthetic BRIL antibody. [PMID:41842660] | Cooper BF, Isom GL | Acta Crystallogr F Struct Biol | 2026 | 0 |
| Bacterial DNA methylases as novel molecular and synthetic biology tools: recent [PMID:40047928] | Flores-Fernández CN, O'Callaghan CA | Applied microbiology and biote | 2025 | 0 |
| Rational multienzyme architecture design with iMARS. [PMID:39855196] | Wang J, Ouyang X, Meng S, Zhao B, Liu L, | Cell | 2025 | 0 |
| ZLN005 Alleviates the Dopaminergic Degeneration via PGC-1α-Mediated Mitochondria [PMID:41400900] | ["Kaur J", "Naqvi S"] | Molecular neurobiology | 2025 | 0 |
| A synthetic protein-level neural network in mammalian cells. [PMID:39666795] | Chen Z, Linton JM, Xia S, Fan X, Yu D, W | Science (New York, N.Y.) | 2024 | 0 |
| Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CX [PMID:38576241] | Liu H, Song P, Zhang H, Zhou F, Ji N, Wa | Journal of extracellular vesic | 2024 | 0 |
| Unstructured polypeptides as a versatile drug delivery technology. [PMID:37075961] | ["Ji Y", "Liu D", "Zhu H", "Bao L", "Cha | Acta biomaterialia | 2023 | 0 |
| Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419] | Persson RM, Tellnes K, Hoven H, Haaverst | Anaesthesia reports | 2022 | 0 |
| Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270] | Fujiya Y, Harada T, Sugawara Y, Akeda Y, | Scientific reports | 2021 | 0 |
| High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700] | Helmuth B, Leichter JJ, Rotjan RD, Casti | Scientific data | 2020 | 0 |
| Fat cadherins in mouse models of degenerative ataxias. [PMID:31695130] | ["Baron O", "Grieshober D", "Dias C", "F | Scientific reports | 2019 | 0 |
| Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metalloth [PMID:29064068] | ["McLeary F", "Rcom-H'cheo-Gauthier A", | Neurotoxicity research | 2018 | 0 |
| Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice. [PMID:30012684] | ["Brooks C", "Snoberger A", "Belcastro M | The Journal of neuroscience : | 2018 | 0 |
| Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases [PMID:14987385] | Fantini J, Garmy N, Mahfoud R, Yahi N | Expert reviews in molecular me | 2002 | 0 |
| Transgenic modelling of neurodegenerative events gathers momentum. [PMID:1726340] | M V Sofroniew; K Staley | Trends in neurosciences | 1991 | 0 |
Multi-agent debates referencing this entity